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TAJ PHARMA INDIA / Product / Wallbrurate®
Wallbrurate ®
Wallbrurate ®Wallbrurate ®Wallbrurate ®Wallbrurate ®

Wallbrurate®

Generic Name

Sodium Valporate and Valporic Acid Tablets


Brand Name

Wallbrurate ®


Dosage Form

Tablets


Strength and Dosage

333mg,145mg


Therapeutic Category

Antiepileptic


Patient Information Leaflet

Summary of Product Characteristics pdfIcon

Product Description


It is a broad spectrum anticonvulsant
Mechanism of Action
Valproate appears to act by multiple mechanisms:

(a) A Phenytoin like frequency dependent prolongation of Na+ channel inactivation
(b) Attenuation of Ca2+ mediated ‘T’ current
(c) Augmentation of release of inhibitory transmitter GABA by inhibiting its degradation as well as increasing its synthesis.

Oral absorption of Valproic acid is good. Peak plasma levels are achieved in 1-4 hrs. It is 90% bound to plasma proteins; 95% metabolized in liver by oxidation and glucuronide conjugation – excreted in urine. Plasma t½ is 15 hours; but anticonvulsant effects are longer lasting


INDICATIONS

Valproic acid is highly effective in absence seizures and is an alternative / adjuvant drug for generalized and partial seizures
To prevent recurrent febrile seizures in children, also used in some cases of Myoclonic and Atonic seizures


DOSAGE

Adults : 200mg 3 times a day, gradually increased at weekly intervals upto a maximum of 600mg 3 times a day according to response.

Children : 10-15mg/kg/day in three divided doses, increase according to response at weekly interval by 5mg/kg/day upto 30-40mg/kg/day

Contraindications
Known hypersensitivity

Special Precautions

Caution in patients in hepatic and renal diseases
Monitor liver function test


ADVERSE DRUG REACTIONS

Anorexia, nausea, vomiting, drowsiness, ataxia are dose related effects Alopecia, hyperammonemia, sedation, vertigo, tremor, nystagmus and confusion can occur with prolonged use Hypersensitivity reactions like rashes and thrombocytopenia

Asymptomatic increase in serum transaminases, rarely hepatitis and pancreatitis It is teratogenic

Status in
1. Pregnancy: Contraindicated
2. Lactation : Use with caution
3. Old age : May be given in reduced dose
4. Children : May be given in dose as advised


INTERACTIONS

Phenytoin: Increases its level by inhibiting metabolism and displacing it from protein binding
Phenobarbital, primidone: Inhibits their metabolism Clonazepam: Simultaneous administration may precipitate absence syndrome Carbamazepine: Induce each other’s metabolism

Presentation Wallbrurate—Blister of 10 Tablets


Note : This product information is intended only for residents of the India. Taj Pharmaceuticals Limited, medicines help to treat and prevent a range of conditions—from the most common to the most challenging—for people around the world.

Information for Health Care Professionals

*** Please consult local Prescribing Information for any product before use. This website is an international information resource for healthcare professionals with an interest in disease management. This website is not intended to replace the advice of a qualified healthcare professional. Above brand is a trademark of the Taj group of companies (Taj Pharmaceuticals Limited).

Additional Information

If you are a distributor, please inquire with us about product , importing and/or marketing our products in your country or region. If you are a consumer, don’t hesitate to contact us about more information for this product.

To inquire more about cost effective Taj Brands products, hospital imports, non-available life saving products, please contact us.

The most common markets for this product include the following state . Please inquire with us if your state is not listed:

North India : Jammu & Kashmir ,Himachal Pradesh,Uttar Pradesh ,Uttaranchal , Punjab ,Haryana.
South India : Kerala, Karnataka ,Tamil Nadu,Andhra Pradesh.
East India : Assam ,Manipur, Meghalaya,West Bengal ,Orissa,Sikkim ,Mizoram, Tripura
West India : Goa ,Gujarat ,Rajasthan ,Maharashtra
Central India : Madhya Pradesh, Chattisgarh

Wallbrurate ® – TAJ PHARMA INDIA | complete detail of medicine Wallbrurate Tablet by Taj Pharmac India., list of drugs similar to Wallbrurate, side effect of Wallbrurate.

Wallbrurate®

Wallbrurate ® – TAJ PHARMA INDIA | complete detail of medicine Wallbrurate Tablet by Taj Pharmac India., list of drugs similar to Wallbrurate, side effect of Wallbrurate.

Wallbrurate®

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