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TAJ PHARMA INDIA / Product / ZOFRACIL(D Pencilamine) 250mg Capsules

ZOFRACIL(D Pencilamine) 250mg Capsules

Generic Name

D Pencilamine

Brand Name


Dosage Form


Strength and Dosage


Therapeutic Category


Patient Information Leaflet

Summary of Product Characteristics pdfIcon


Treating Wilson disease (excess copper in the body), severe rheumatoid arthritis that has not responded to other treatments, and cystinuria (excess amino acids in the urine, which causes kidney stones). It may also be used for other conditions as determined by your doctor.

D Penicillamine is a chelating agent. It works by removing excess copper in patients with Wilson disease, reducing excess cystine in patients with cystinuria, and reducing disease activity in patients with rheumatoid arthritis.

Do NOT use D penicillamine if:

• you are allergic to any ingredient in penicillamine or to penicillin
• you are pregnant or are breast-feeding
• you have a history of aplastic anemia or agranulocytosis (decreased number of white blood cells) due to penicillamine use
• you have a history of kidney problems (rheumatoid arthritis patients only), blood in the urine, or pemphigus (blistering skin disease)
• you are taking gold therapy (eg, gold salts), antimalarial or cytotoxic medicines (eg, quinine, carboplatin), oxyphenbutazone, or phenylbutazone

Contact your doctor or health care provider right away if any of these apply to you.

Before using D penicillamine

Some medical conditions may interact with penicillamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you are scheduled for surgery
• if you have Goodpasture syndrome, myasthenia gravis, aplastic anemia, or decreased blood platelets or white blood cells

Some MEDICINES MAY INTERACT with penicillamine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Antimalarial medicines (eg, atovaquone), cytotoxic medicines (eg, carboplatin, quinine), gold salts, oxyphenbutazone, or phenylbutazone because the risk of side effects, such as kidney problems and blood disorders, may be increased
Digoxin because its effectiveness may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if penicillamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use penicillamine:

Use penicillamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take penicillamine on an empty stomach (1 hour before meals or 2 hours after meals).
• Take penicillamine at least 2 hours before or after other medicines containing aluminum or magnesium (antacids), iron, or vitamins that contain iron.
• If you are taking penicillamine for cystinuria, drink plenty of water while taking penicillamine. Drink a pint (16 ounces [480 mL]) at bedtime and another pint during the night, unless directed otherwise by your doctor.
• It may take 1 to 3 months for penicillamine to work.
• If you miss a dose of penicillamine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use penicillamine.

side effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; loss of appetite; mild stomach pain; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding or bruising; blood in the urine; burning, itching, peeling, or redness of skin; changes in taste; chills; cough; dark urine; difficult urination; fever; general feeling of discomfort; joint pain; muscle weakness; severe stomach pain; shortness of breath; skin lesions; sore throat; swelling of the feet or legs; vision problems; weight gain; wheezing.

• If you have any questions about penicillamine, please talk with your doctor, pharmacist, or other health care provider.
• Penicillamine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.
• Check with your pharmacist about how to dispose of unused medicine.
Store penicillamine at room temperature, 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep penicillamine out of the reach of children and away from pets.

“Note : This product information is intended only for residents of the India. Taj Pharmaceuticals Limited, medicines help to treat and prevent a range of conditions—from the most common to the most challenging—for people around the world.

Information for Health Care Professionals

*** Please consult local Prescribing Information for any product before use. This website is an international information resource for healthcare professionals with an interest in disease management. This website is not intended to replace the advice of a qualified healthcare professional. Above brand is a trademark of the Taj group of companies (Taj Pharmaceuticals Limited).

Additional Information

If you are a distributor, please inquire with us about product , importing and/or marketing our products in your country or region. If you are a consumer, don’t hesitate to contact us about more information for this product.

To inquire more about cost effective Taj Brands products, hospital imports, non-available life saving products, please contact us.

The most common markets for this product include the following state . Please inquire with us if your state is not listed:

North India : Jammu & Kashmir ,Himachal Pradesh,Uttar Pradesh ,Uttaranchal , Punjab ,Haryana.
South India : Kerala, Karnataka ,Tamil Nadu,Andhra Pradesh.
East India : Assam ,Manipur, Meghalaya,West Bengal ,Orissa,Sikkim ,Mizoram, Tripura
West India : Goa ,Gujarat ,Rajasthan ,Maharashtra
Central India : Madhya Pradesh, Chattisgarh

ZOFRACIL(D Pencilamine) 250mg Capsules – TAJ PHARMA INDIA | Treating Wilson disease (excess copper in the body), severe rheumatoid arthritis that has not responded to other treatments, and cystinuria (excess amino acids in the urine, which causes kidney stones).

ZOFRACIL(D Pencilamine) 250mg Capsules – TAJ PHARMA INDIA


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